GATA Transcription Factors and Cardiac Development

Semin Cell Dev Biol. 1999 Feb;10(1):85-91. doi: 10.1006/scdb.1998.0281.

Abstract

Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / physiology
  • Cardiomegaly / genetics
  • Chickens
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • GATA4 Transcription Factor
  • GATA5 Transcription Factor
  • GATA6 Transcription Factor
  • Gene Expression Regulation, Developmental
  • Heart / embryology*
  • Heart / growth & development
  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / physiology
  • Humans
  • Mice
  • Myocardium / metabolism
  • Rats
  • Signal Transduction / genetics
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Xenopus
  • Xenopus Proteins*

Substances

  • Bone Morphogenetic Proteins
  • DNA-Binding Proteins
  • GATA-5a protein, Xenopus
  • GATA-5b protein, Xenopus
  • GATA4 Transcription Factor
  • GATA4 protein, Xenopus
  • GATA5 Transcription Factor
  • GATA5 protein, human
  • GATA6 Transcription Factor
  • GATA6 protein, Xenopus
  • GATA6 protein, human
  • Gata5 protein, mouse
  • Gata5 protein, rat
  • Gata6 protein, mouse
  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins
  • NKX2-5 protein, Xenopus
  • NKX2-5 protein, human
  • Nkx2-5 protein, mouse
  • Transcription Factors
  • Xenopus Proteins