Abstract
An irregular tumor shadow, seen on the left kidney in a 48-year-old woman by computed tomography, was pathologically diagnosed as 'angiomyolipoma'. HMB-45 immunoreactivity distinguished angiomyolipoma from renal cell carcinoma of sarcomatoid type. The amyloid deposition was limited to the tumor. M-protein and Bence-Jones protein were negative. For amyloid protein characterization, immunohistochemical studies were performed with antiamyloid A, anti-kappa, anti-lambda, anti-prealbumin and anti-beta-2 microglobulin, but none reacted with the amyloid. This is the first documented case of amyloid deposition in angiomyolipoma and may represent a novel precursor protein of amyloid.
MeSH terms
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Amyloid / immunology
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Amyloid / metabolism*
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Amyloid / ultrastructure
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Amyloidosis / metabolism
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Amyloidosis / pathology*
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Amyloidosis / surgery
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Angiomyolipoma / metabolism
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Angiomyolipoma / pathology*
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Angiomyolipoma / surgery
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Antigens, Neoplasm / metabolism
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Biomarkers, Tumor / metabolism
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Carcinoma, Renal Cell / metabolism
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Carcinoma, Renal Cell / pathology
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Diagnosis, Differential
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Female
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Humans
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Immunoenzyme Techniques
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Kidney Neoplasms / metabolism
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Kidney Neoplasms / pathology*
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Kidney Neoplasms / surgery
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Melanoma-Specific Antigens
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Middle Aged
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Neoplasm Proteins / metabolism
Substances
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Amyloid
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Antigens, Neoplasm
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Biomarkers, Tumor
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Melanoma-Specific Antigens
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Neoplasm Proteins