Genetic analysis of B cell antigen receptor signaling

Annu Rev Immunol. 1999;17:555-92. doi: 10.1146/annurev.immunol.17.1.555.


In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma 2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma 2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Cell Differentiation
  • GTP-Binding Proteins / metabolism
  • Humans
  • Lipid Metabolism
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, B-Cell / genetics*
  • Signal Transduction


  • Receptors, Antigen, B-Cell
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • Protein Tyrosine Phosphatases
  • GTP-Binding Proteins