Selection of the T cell repertoire

Annu Rev Immunol. 1999;17:829-74. doi: 10.1146/annurev.immunol.17.1.829.

Abstract

Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autoimmune Diseases / immunology
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cell Differentiation
  • Cell Survival
  • Humans
  • Isoenzymes / metabolism
  • Major Histocompatibility Complex
  • Models, Biological
  • Peptides / immunology
  • Phospholipase C gamma
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / metabolism
  • Receptors, Tumor Necrosis Factor / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Transcription Factors / metabolism
  • Type C Phospholipases / metabolism

Substances

  • Isoenzymes
  • Peptides
  • Receptors, Antigen, T-Cell
  • Receptors, Tumor Necrosis Factor
  • Transcription Factors
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Type C Phospholipases
  • Phospholipase C gamma