Genetic basis of cardiomyopathy

Curr Opin Cardiol. 1999 May;14(3):225-9. doi: 10.1097/00001573-199905000-00006.


The molecular basis of cardiac growth and development is a fundamental question that has intrigued many investigators in cardiovascular research. Adult cardiomyocytes are terminally differentiated and lose their ability to proliferate shortly after birth; however, in response to injury, myocytes have the capacity to synthesize new DNA and exhibit plasticity by a compensatory growth response, as is shown by re-expression of the fetal isoforms of many muscle-specific genes, which is characteristic of the proliferative response. The long-term effects of these compensatory responses may lead to the development and progression of diseases such as hypertrophic cardiomyopathy and dilated cardiomyopathy, because of a single point mutation. This concept has engaged scientists to investigate human models to explore the molecular basis of hypertrophy or dilation of the myocardium.

Publication types

  • Review

MeSH terms

  • Cardiomyopathies / genetics*
  • Gene Expression Regulation
  • Genotype
  • Humans
  • Muscle Proteins / genetics
  • Myocardium / cytology
  • Myocardium / metabolism
  • Myocardium / pathology
  • Phenotype


  • Muscle Proteins