CIIV, MIIC and other compartments for MHC class II loading

Eur J Immunol. 1999 May;29(5):1421-5. doi: 10.1002/(SICI)1521-4141(199905)29:05<1421::AID-IMMU1421>3.0.CO;2-C.


Virtually every endocytic compartment has been claimed to be an MIIC, a site where class II molecules accumulate. Here, it is argued that the definition of MIIC is not accurate and often pointless. MIIC can better be used as a working title for a collection of late endocytic compartments that contain the goodies necessary for efficient peptide loading of class II molecules.

MeSH terms

  • Histocompatibility Antigens Class II / immunology*
  • Humans


  • Histocompatibility Antigens Class II