Multidrug resistance: Versatile drug sensors of bacterial cells

Curr Biol. 1999 Jun 3;9(11):R403-7. doi: 10.1016/s0960-9822(99)80254-1.


One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents
  • Bacterial Proteins / metabolism
  • Binding Sites
  • Carrier Proteins / metabolism
  • Cations
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple / physiology*
  • Membrane Transport Proteins*
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • BmrR protein, bacteria
  • Carrier Proteins
  • Cations
  • Membrane Transport Proteins
  • Trans-Activators
  • Bmr protein, Bacillus subtilis