Effectiveness of oxybutynin hydrochloride in the treatment of enuresis nocturna--a clinical and urodynamic study

Scand J Urol Nephrol. 1999 Apr;33(2):115-8. doi: 10.1080/003655999750016096.

Abstract

Objective: To find the efficacy and optimal dosage of oxybutynin HC1 in a group of enuretic children, who were non-responsive to imipramine.

Material and methods: Thirty-six patients with enuresis who were non-responsive to imipramine were urodynamically assessed and subsequently treated with oxybutynin hydrochloride (HCl). Patients with inadequate bladder storage function (IBSF) were started on 10-mg daily oxybutynin HCl for one month. If the initial treatment was found to be inadequate, the dose was increased to 15 mg daily. The dose in patients who were non-responsive to 15-mg daily dose was increased to 20-mg daily dose. Patients who were normal urodynamically were treated with a dose of 15 mg daily for one month.

Results: Before the treatment, 17 patients had IBSF (47.2%). The majority of the patients (88.2%) with IBSF were responsive to the 15-mg daily oxybutynin HCl. The treatment in patients with normal bladder function was generally unsuccessful.

Conclusions: Oxybutynin HCl in sufficient dosages seems to be effective in the treatment of enuretic patients with IBSF.

MeSH terms

  • Adolescent
  • Child
  • Cholinergic Antagonists / administration & dosage
  • Cholinergic Antagonists / therapeutic use*
  • Dose-Response Relationship, Drug
  • Enuresis / drug therapy*
  • Humans
  • Mandelic Acids / administration & dosage
  • Mandelic Acids / therapeutic use*
  • Time Factors
  • Urodynamics / drug effects

Substances

  • Cholinergic Antagonists
  • Mandelic Acids
  • oxybutynin