The Survival of Monolayers of Cells Growing in Clusters Irradiated by 211At Appended to the Cell Surfaces

Radiat Res. 1999 Jun;151(6):750-3.

Abstract

A model of cell survival is described for the case of closely packed clusters of cells growing in monolayers. For alpha-particle decays on the cell surfaces, it is shown that cross-firing between cells produces nonuniform dose distributions within the cluster and that cells in larger clusters are exposed on average to greater doses. The model is used to simulate the survival of SK-MEL-28 human melanoma cells labeled with different radiolabeled monoclonal antibodies. The survival data suggest that this cell line is more sensitive to high-LET radiation than previously thought.

MeSH terms

  • Alpha Particles
  • Astatine / therapeutic use*
  • Cell Survival / radiation effects
  • Humans
  • Linear Energy Transfer
  • Melanoma / radiotherapy*
  • Tumor Cells, Cultured

Substances

  • Astatine