Human Herpes virus-6 Seroprevalence and Leukaemias: A Case-Control Study. GIMEMA (Gruppo Italiano Malattie Ematologiche Dell' Adulto)

Br J Cancer. 1999 Jun;80(7):1103-6. doi: 10.1038/sj.bjc.6690471.


The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multicentre case-control study. An association between increased HHV-6 seropositivity and geometric mean titre ratio with AML was shown: P for trend = 0.022, adjusted odds ratio 1.20, 95% confidence interval 1.07-1.33 respectively. No association was found between HHV-6 and ALL, CML or RAEB.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Refractory, with Excess of Blasts / epidemiology*
  • Anemia, Refractory, with Excess of Blasts / virology
  • Antibodies, Viral / blood*
  • Case-Control Studies
  • Female
  • Herpesvirus 6, Human / immunology*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / virology
  • Leukemia, Myeloid, Acute / epidemiology*
  • Leukemia, Myeloid, Acute / virology
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
  • Risk Factors
  • Seroepidemiologic Studies


  • Antibodies, Viral