Targeting of marrow-derived astrocytes to the ischemic brain

Neuroreport. 1999 Apr 26;10(6):1289-92. doi: 10.1097/00001756-199904260-00025.


Bone marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / cytology*
  • Astrocytes / physiology
  • Bone Marrow Cells / cytology*
  • Bone Marrow Cells / physiology
  • Bone Marrow Transplantation / physiology*
  • Brain Ischemia / pathology*
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Immunohistochemistry
  • In Situ Hybridization
  • Male
  • Microscopy, Confocal
  • Rats
  • Rats, Inbred SHR
  • Y Chromosome


  • Glial Fibrillary Acidic Protein