CD44s, E-cadherin and PCNA as markers for progression in renal cell carcinoma

Anticancer Res. 1999 Mar-Apr;19(2C):1513-7.


CD44s, E-cadherin and PCNA play an important role in the tumorigenesis of renal cell carcinoma (RCC), although their significance in the clinical progression of RCC is still not clear. In n = 137 cases of operatively resected RCC the expression of CD44s, E-cadherin and PCNA was semiquantitatively analyzed by the APAAP immunohistochemical method. The mean observation period of the n = 74 (54%) of patients with no evidence of disease was 52.6 months and for the n = 63 (46%) patients with progressive disease was 18.7 months. The mean progression free period occurring with absent or low levels of CD44s and PCNA expression was 79 and 118+ months, and with strong expression was 12 and 18 months (p < 0.001), respectively. With strong E-cadherin expression the progression free period was 110+ months, and with low expression 61 months (p = 0.01). A high CD44s/E-cadherin ratio and an above average PCNA expression were identified as independent prognostic parameters for the progression tendency of RCC.

MeSH terms

  • Antigens, CD / analysis*
  • Biomarkers, Tumor / analysis*
  • Cadherins / analysis*
  • Carcinoma, Renal Cell / mortality
  • Carcinoma, Renal Cell / pathology*
  • Carcinoma, Renal Cell / surgery
  • Disease Progression
  • Humans
  • Hyaluronan Receptors / analysis*
  • Immunohistochemistry
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Lymphatic Metastasis
  • Neoplasm Metastasis
  • Nephrectomy
  • Proliferating Cell Nuclear Antigen / analysis*
  • Survival Analysis


  • Antigens, CD
  • Biomarkers, Tumor
  • Cadherins
  • Hyaluronan Receptors
  • Proliferating Cell Nuclear Antigen