Giant cell angiofibroma of the orbit and eyelid

Ophthalmology. 1999 Jun;106(6):1223-9. doi: 10.1016/S0161-6420(99)90270-1.


Purpose: To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma.

Design: Observational case series.

Main outcome measures: Clinical and histopathologic features of giant cell angiofibroma.

Methods: Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma.

Results: A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin.

Conclusion: Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiofibroma / chemistry
  • Angiofibroma / diagnostic imaging
  • Angiofibroma / pathology*
  • Angiofibroma / ultrastructure
  • Antigens, CD34 / analysis
  • Diagnosis, Differential
  • Eyelid Neoplasms / chemistry
  • Eyelid Neoplasms / diagnostic imaging
  • Eyelid Neoplasms / pathology*
  • Eyelid Neoplasms / ultrastructure
  • Female
  • Giant Cell Tumors / chemistry
  • Giant Cell Tumors / diagnostic imaging
  • Giant Cell Tumors / pathology*
  • Giant Cell Tumors / ultrastructure
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Orbital Neoplasms / chemistry
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / pathology*
  • Orbital Neoplasms / ultrastructure
  • Tomography, X-Ray Computed
  • Vimentin / analysis


  • Antigens, CD34
  • Vimentin