Differential expression of Islet-1 in neural crest-derived ganglia: Islet-1 + dorsal root ganglion cells are post-mitotic and Islet-1 + sympathetic ganglion cells are still cycling

Brain Res Dev Brain Res. 1999 Jun 8;115(1):89-92. doi: 10.1016/s0165-3806(99)00054-1.


The Islet-1 antigen is an early marker of differentiation of neural tube cells, and is expressed in many other embryonic cells as well. It had been reported that Islet-1 is expressed only in post-mitotic sympathetic neuroblasts in vitro, unlike other differentiation markers. We have double-labeled St. 23 chick embryos for bromodeoxyuridine (BrDU) and Islet-1 and found that neural tube and dorsal root ganglion (DRG) cells express Islet-1 after leaving the cell cycle, while sympathetic ganglion (SG) cells express Islet-1 while still dividing.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Differentiation / physiology
  • Chick Embryo
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / embryology
  • Ganglia, Spinal / metabolism*
  • Ganglia, Sympathetic / cytology
  • Ganglia, Sympathetic / embryology
  • Ganglia, Sympathetic / metabolism*
  • Homeodomain Proteins / biosynthesis*
  • LIM-Homeodomain Proteins
  • Mitosis / physiology*
  • Nerve Tissue Proteins*
  • Neural Crest / metabolism*
  • Transcription Factors


  • Homeodomain Proteins
  • LIM-Homeodomain Proteins
  • Nerve Tissue Proteins
  • Transcription Factors
  • insulin gene enhancer binding protein Isl-1