Mammalian Krüppel-like transcription factors: more than just a pretty finger

Trends Biochem Sci. 1999 Jun;24(6):236-40. doi: 10.1016/s0968-0004(99)01406-1.


The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in their zinc-finger domains but differ elsewhere. Analysis of these differences is illuminating specific mechanisms by which transcription is regulated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • DNA-Binding Proteins / physiology*
  • Kruppel-Like Transcription Factors
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Multigene Family
  • Phylogeny
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Repressor Proteins
  • Transcription Factors