Protective mechanisms against toxic electrophiles in Escherischia coli

Trends Microbiol. 1999 Jun;7(6):242-7. doi: 10.1016/s0966-842x(99)01510-3.

Abstract

Escherichia coli are exposed to toxic electrophiles from both endogenous and exogenous sources. To survive, E. coli have developed novel protective mechanisms that appear unique to bacteria. In the absence of one of these mechanisms, electrophiles induce rapid killing. Hence it appears that electrophile-protective mechanisms represent novel targets for antibacterial drug research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiporters / metabolism
  • Bacterial Proteins / metabolism
  • DNA, Bacterial / metabolism
  • Escherichia coli / physiology*
  • Escherichia coli Proteins*
  • Glutathione / metabolism
  • Hydrogen-Ion Concentration
  • Potassium Channels / metabolism
  • Potassium-Hydrogen Antiporters
  • Pyruvaldehyde / adverse effects
  • Pyruvaldehyde / metabolism*

Substances

  • Antiporters
  • Bacterial Proteins
  • DNA, Bacterial
  • Escherichia coli Proteins
  • Potassium Channels
  • Potassium-Hydrogen Antiporters
  • KefC protein, E coli
  • Pyruvaldehyde
  • Glutathione