The matrilins: a novel family of oligomeric extracellular matrix proteins

Matrix Biol. 1999 Feb;18(1):55-64. doi: 10.1016/s0945-053x(98)00006-7.


The matrilin family at present has four members that all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil alpha-helical module. The first member of the family, matrilin-1 (previously called cartilage matrix protein or CMP), is expressed mainly in cartilage. Matrilin-3 has a similar tissue distribution, while matrilin-2 and -4 occur in a wide variety of extracellular matrices. Matrilin-1 is associated with cartilage proteoglycans as well as being a component of both collagen-dependent and collagen-independent fibrils and on the basis of the related structures other matrilins may play similar roles. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cartilage Oligomeric Matrix Protein
  • Evolution, Molecular
  • Extracellular Matrix Proteins / chemistry*
  • Extracellular Matrix Proteins / genetics
  • Gene Expression Regulation
  • Glycoproteins / chemistry*
  • Glycoproteins / genetics
  • Humans
  • Matrilin Proteins
  • Protein Conformation


  • Cartilage Oligomeric Matrix Protein
  • Extracellular Matrix Proteins
  • Glycoproteins
  • MATN1 protein, human
  • MATN2 protein, human
  • MATN4 protein, human
  • Matrilin Proteins
  • TSP5 protein, human