Antibody-mediated red blood cell agglutination resulting in spontaneous echocardiographic contrast

M R Miller; W R Thompson; J F Casella; P J Spevak

doi:10.1007/s002469900465

Antibody-mediated red blood cell agglutination resulting in spontaneous echocardiographic contrast

Pediatr Cardiol. 1999 Jul-Aug;20(4):287-9. doi: 10.1007/s002469900465.

Authors

M R Miller¹, W R Thompson, J F Casella, P J Spevak

Affiliation

¹ Division of Pediatric Cardiology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.

PMID: 10368455
DOI: 10.1007/s002469900465

Abstract

Spontaneous echocardiographic contrast is well reported in states of low flow and low shear stress, and the primary blood component involved has been reported as red blood cells via rouleaux formation. This report describes the occurrence of spontaneous echocardiographic contrast from a unique mechanism of IgM-mediated red blood cell agglutination and describes the clinical sequelae.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Hemolytic, Autoimmune / diagnostic imaging*
Anemia, Hemolytic, Autoimmune / immunology
Antibodies, Anti-Idiotypic / immunology*
Autopsy
Cardiac Output, Low / diagnostic imaging
Cardiac Output, Low / etiology
Child
Echocardiography*
Erythrocyte Aggregation / diagnostic imaging*
Erythrocyte Aggregation / immunology
Fatal Outcome
Female
Humans
Immunoglobulin M / immunology*

Substances

Antibodies, Anti-Idiotypic
Immunoglobulin M