The effects of knee extensor and flexor muscle training on the timed-up-and-go test in individuals with rheumatoid arthritis

Physiother Res Int. 1999;4(1):55-67. doi: 10.1002/pri.1999.4.1.55.


Background and purpose: Rheumatoid arthritis frequently results in functional impairment. This study investigated the effect of a specific exercise regimen on function.

Method: A randomized controlled assessor-blinded (N = 36) compared the effect of knee extensor and flexor muscle training on pain, the timed up and go (TUG) test and the Health Assessment Questionnaire in subjects with non-acute rheumatoid arthritis.

Results: Knee extensor and flexor muscle training increased isokinetic torques at speeds of 60 degrees/sec-1 and 120 degrees/sec-1 as measured by an isokinetic dynamometer (p = 0.02-0.003). The experimental group experienced a reduction in pain (p = 0.03), an improvement in TUG time (p = 0.01) and in function as measured by the Health Assessment Questionnaire (p = 0.04).

Conclusions: Specific knee muscle training can be administered safely in people with non-acute rheumatoid arthritis, and may produce functional benefits.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Analysis of Variance
  • Arthritis, Rheumatoid / rehabilitation*
  • Biomechanical Phenomena
  • Disability Evaluation
  • Exercise Therapy / methods*
  • Female
  • Humans
  • Knee Joint*
  • Male
  • Middle Aged
  • Movement / physiology
  • Muscle Contraction / physiology
  • Pain Measurement
  • Torque