Advances in Y chromosome mapping

Curr Opin Obstet Gynecol. 1999 Jun;11(3):275-81. doi: 10.1097/00001703-199906000-00008.

Abstract

The human Y chromosome has long been recognized as being responsible for sex determination. In fact, it also encodes more than 30 genes and gene families that participate in a variety of cellular functions, including bone development, tooth growth, and spermatogenesis. De-novo deletion of Y chromosome segments that contain spermatogenesis genes occurs frequently, resulting in low sperm production and male infertility. This article reviews our current knowledge of the structure and function of the Y chromosome is reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Chromosome Mapping*
  • Gene Deletion
  • Genetic Variation
  • Humans
  • Infertility, Male / genetics*
  • Male
  • Phenotype
  • Sex Chromosome Aberrations / genetics*
  • Sex Determination Processes
  • Spermatogenesis / genetics*
  • Y Chromosome* / genetics