This article is intended to stimulate interdisciplinary research by social, behavioral, and biomedical researchers to solve some of the problems for persons with Alzheimer disease who suffer from behavioral symptoms. We identify the need for using conceptually based measures that have adequate reliability and validity to operationalize indicators of psychological well-being, suggest instruments to assess mood, engagement, agitation, resistiveness and comfort, and pose research questions to explore responses to active involvement (individual or group), passive involvement, lack of activity, aversive activity (related to activities of daily living), and limitation of activity (restraints) in persons with dementia. Answers to the research questions posed in this article will lead to expanded knowledge and can redefine how we give care to those in need.