Gastrulation in Drosophila: the logic and the cellular mechanisms

EMBO J. 1999 Jun 15;18(12):3187-92. doi: 10.1093/emboj/18.12.3187.


The egg contains a set of molecules that can be used to trigger cell-shape changes leading to morphogenetic movements. The temporally and spatially controlled activation of these molecules, and hence the choreography of gastrulation movements, is determined by region-specific expression of transcription factors which turn on a set of downstream targets whose products mediate the successive steps of gastrulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Patterning
  • Cell Size
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / embryology*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Embryo, Nonmammalian / physiology*
  • Gastrula / cytology
  • Gastrula / metabolism
  • Gastrula / physiology*
  • Gene Expression Regulation, Developmental
  • Morphogenesis