CART peptides: novel addiction- and feeding-related neuropeptides

Trends Neurosci. 1999 Jul;22(7):316-20. doi: 10.1016/s0166-2236(98)01377-0.


CART peptides are novel, putative brain-gut neurotransmitters and co-transmitters that probably have a role in drug abuse, the control of feeding behavior, sensory processing, stress and development. They are abundant, processed and apparently released. Exogenously applied peptides cause inhibition of feeding and have neurotrophic properties. Although the precise sequences, relative abundance and efficacy of all CART peptides are currently being determined, small molecules that are active at putative CART receptors could have substantial therapeutic promise.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Brain Chemistry
  • Brain Mapping*
  • Eating / physiology*
  • Haplorhini
  • Humans
  • Nerve Tissue Proteins / biosynthesis
  • Nerve Tissue Proteins / physiology*
  • Rats
  • Sheep
  • Substance-Related Disorders / physiopathology


  • Nerve Tissue Proteins
  • cocaine- and amphetamine-regulated transcript protein