Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with aseptic meningitis

J Neurol Sci. 1999 Mar 1;163(2):187-91. doi: 10.1016/s0022-510x(99)00037-4.


Histiocytic necrotizing lymphadenitis, or Kikuchi's disease (KD), is a self-limited clinicopathologic entity recognized increasingly worldwide. A 27-year-old man with cervical lymphadenopathy and fever who was diagnosed with KD developed mild headache with no nuchal rigidity. The cerebrospinal fluid (CSF) was sterile and contained 78 white blood cells/mm3 with lymphocytes predominating, accompanied by smaller numbers of monocytes and granulocytes. This abnormality normalized spontaneously over 5 weeks. Eleven similar cases have been reported, all but one from Japan. The development of meningitis in KD was observed in four (9.8%) of 41 KD patients we have treated, suggesting that the meningitis was related to KD and not merely coincidental.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Headache
  • Histiocytic Necrotizing Lymphadenitis / cerebrospinal fluid
  • Histiocytic Necrotizing Lymphadenitis / complications*
  • Histiocytic Necrotizing Lymphadenitis / pathology
  • Histiocytic Necrotizing Lymphadenitis / physiopathology
  • Humans
  • Lymph Nodes / pathology
  • Male
  • Meningitis, Aseptic / complications*
  • Meningitis, Aseptic / pathology
  • Meningitis, Aseptic / physiopathology