Neuropathic pain: aetiology, symptoms, mechanisms, and management

Lancet. 1999 Jun 5;353(9168):1959-64. doi: 10.1016/S0140-6736(99)01307-0.


We highlight current theories about peripheral neuropathic pain and show that progress in management is contingent on targeting treatment not at the aetiological factors or the symptoms but at the mechanisms that operate to produce the symptoms. This approach will require substantial progress in our understanding of the pathophysiology of neuropathic pain, the development of accurate diagnostic tools to discover what mechanisms contribute to the pain syndrome in an individual, and effective treatments aimed specifically at the mechanisms.

Publication types

  • Review

MeSH terms

  • Humans
  • Pain Threshold / physiology
  • Pain* / drug therapy
  • Pain* / etiology
  • Pain* / physiopathology
  • Peripheral Nerves* / physiopathology
  • Peripheral Nervous System Diseases* / drug therapy
  • Peripheral Nervous System Diseases* / etiology
  • Peripheral Nervous System Diseases* / physiopathology