Stem cells, pre-progenitor cells and lineage-committed cells: are our dogmas correct?

Ann N Y Acad Sci. 1999 Apr 30;872:289-303; discussion 303-4. doi: 10.1111/j.1749-6632.1999.tb08473.x.


Recent developments warrant careful reexamination of several of the central dogmas of hematopoiesis. The bioassays previously used may have predetermined which subsets of hematopoietic stem cells are regarded as having long-term repopulating activity and thus have produced misleading data. Lineage commitment in multipotential cells has been regarded as an immutable stochastic process but may be a process that can be modified by extrinsic signaling. Finally, loss of self-renewal activity has been regarded as progressive and irreversible but this response to signaling can be blocked by cytokine-inducible modulating proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Leukopoiesis
  • Models, Biological