Current theories on the causes of inflammatory bowel disease

Gastroenterol Clin North Am. 1999 Jun;28(2):283-96. doi: 10.1016/s0889-8553(05)70057-1.


The understanding of the pathogenesis of CD and UC has greatly expanded over the last decade. The combination of abnormalities in the immune system, the contribution of nonimmune cells in the intestinal mucosa, a variety of genetic risk determinants, and random environmental factors may all be necessary to induce what clinically presents as IBD. It is likely that several agents can initiate an immune response that in the intestinal microenvironment and the genetic background of the patient finally leads to pathology.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Disease Models, Animal
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Inflammatory Bowel Diseases* / drug therapy
  • Inflammatory Bowel Diseases* / etiology
  • Inflammatory Bowel Diseases* / immunology
  • Inflammatory Bowel Diseases* / metabolism
  • Inflammatory Bowel Diseases* / microbiology
  • Recurrence


  • Immunosuppressive Agents