Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations

Genomics. 1999 Jun 15;58(3):310-2. doi: 10.1006/geno.1999.5833.

Abstract

Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target of cancer chemotherapy. A tandem repeat sequence in a TS promoter enhancer region (TSER) was recently identified. Polymorphic variation affected in vitro expression levels of the gene. We evaluated the influence of ethnicity on TSER genotype. Allele frequency was similar in Caucasian and Southwest Asian subjects. However, homozygous triple repeat subjects were twice as common in Chinese subjects (67%) than in Caucasian subjects (38%). This demonstrates significant ethnic variation in a TS gene regulatory element which may have significant impact on pyrimidine homeostasis and drug therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Asian Continental Ancestry Group / genetics*
  • DNA / chemistry
  • DNA / genetics
  • Enhancer Elements, Genetic*
  • European Continental Ancestry Group / genetics*
  • Family Health
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Polymorphism, Genetic
  • Regulatory Sequences, Nucleic Acid
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA
  • Thymidylate Synthase / genetics*

Substances

  • DNA
  • Thymidylate Synthase

Associated data

  • GENBANK/AF127519
  • GENBANK/AF127520