Apoptosis induced by propolis in human hepatocellular carcinoma cell line

Int J Mol Med. 1999 Jul;4(1):29-32. doi: 10.3892/ijmm.4.1.29.

Abstract

Propolis has been reported to exhibit a wide spectrum of activities including antibiotic, antiviral, anti-inflammatory, immunostimulatory and tumor carcinostatic properties. We showed propolis induced apoptosis in a human hepatoma cell line (SNU449) by FITC-Annexin V/PI staining. We also compared the apoptosis inducing effect between Korean and Commercial (Sigma # p-1010) propolis. There was no difference on apoptosis between them.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annexin A5 / metabolism
  • Apoptosis / drug effects*
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology
  • DNA Fragmentation / drug effects
  • Fluorescein-5-isothiocyanate
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • Propidium
  • Propolis / pharmacology*
  • Tumor Cells, Cultured

Substances

  • Annexin A5
  • Propidium
  • Propolis
  • Fluorescein-5-isothiocyanate