Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer

Int J Mol Med. 1999 Jul;4(1):73-7. doi: 10.3892/ijmm.4.1.73.


Proteolytic activity of cancer cells is an important factor in metastasis. This study examined the relationship between MMP-1 expression of gastric cancer cells and peritoneal metastasis. MMP-1 expression was found in 76/103 (75.2%) cases examined and was significantly associated with both peritoneal metastasis and lymph node metastasis (p<0.05, respectively). The prognosis of patients with MMP-1 positive tumor was significantly worse than that of patients with MMP-1 negative tumor (p<0.05). These findings suggested that MMP-1 might be a prognostic factor in case of advanced gastric cancer and might be useful in determining whether or not adjuvant therapy was indicated for patients at high risk of peritoneal recurrence.

MeSH terms

  • Adult
  • Aged
  • Collagenases / metabolism*
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Male
  • Matrix Metalloproteinase 1
  • Middle Aged
  • Neoplasm Invasiveness
  • Peritoneal Neoplasms / enzymology
  • Peritoneal Neoplasms / secondary
  • Prognosis
  • Recurrence
  • Stomach Neoplasms / enzymology*
  • Stomach Neoplasms / pathology


  • Collagenases
  • Matrix Metalloproteinase 1