Diurnal changes in intraepithelial lymphocytes (IELs) in the small intestine of mice

Exp Anim. 1999 Apr;48(2):115-8. doi: 10.1538/expanim.48.115.


Diurnal changes in small intestinal intraepithelial lymphocytes (IELs) were examined in 8- to 10-week-old BALB/cA male mice. The ratio of T cell subsets expressing CD8 alpha alpha homodimer/CD8 alpha beta heterodimer was found to be higher in the dark period than that in the light period. Increased expression of Thy-1.2 on gamma delta T cells was also observed in the light period. No significant changes were found in other subsets. This is the first report to document diurnal changes in the small intestinal IELs in mice.

MeSH terms

  • Animals
  • Circadian Rhythm*
  • Epithelial Cells / immunology*
  • Intestines / cytology
  • Intestines / immunology*
  • Lymphocyte Subsets
  • Male
  • Mice
  • Mice, Inbred BALB C
  • T-Lymphocytes / immunology*