Cell cycle: driving the centrosome cycle

Curr Biol. 1999 Jun 17;9(12):R449-52. doi: 10.1016/s0960-9822(99)80279-6.

Abstract

Cyclin-dependent kinases (Cdks) control major transitions as cells pass through the cell cycle. It has recently been shown that centrosome duplication in vertebrates requires Cdk2 activity and can be driven solely by Cdk2-cyclin E complexes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CDC2-CDC28 Kinases*
  • Cell Cycle / physiology*
  • Centrosome / physiology*
  • Cyclin E / physiology
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases / physiology
  • DNA Replication / physiology
  • Protein Serine-Threonine Kinases / physiology
  • Spindle Apparatus / physiology

Substances

  • Cyclin E
  • Protein Serine-Threonine Kinases
  • CDC2-CDC28 Kinases
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases