Histidine kinases and two-component signal transduction systems

Chem Biol. 1999 Jun;6(6):R167-75. doi: 10.1016/S1074-5521(99)80044-1.

Abstract

The phosphorylation of histidine is the first step in many signal transduction cascades in bacteria, yeast and higher plants. The transfer of a very reactive phosphoryl group from phosphorylated histidine kinase to an acceptor is an essential step in many cellular signaling responses.

Publication types

  • Review

MeSH terms

  • Bacteria / drug effects
  • Bacteria / genetics
  • Bacteria / metabolism
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial
  • Histidine / analogs & derivatives
  • Histidine / chemistry
  • Histidine / metabolism
  • Histidine Kinase
  • Magnetic Resonance Spectroscopy
  • Models, Biological
  • Protein Kinase Inhibitors
  • Protein Kinases / metabolism*
  • Signal Transduction / physiology*

Substances

  • Protein Kinase Inhibitors
  • Histidine
  • Protein Kinases
  • Histidine Kinase
  • phosphohistidine