T cell antigen-receptor signal transduction

Curr Opin Immunol. 1999 Jun;11(3):242-8. doi: 10.1016/s0952-7915(99)80040-5.

Abstract

During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways. TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effectors of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Calcium / metabolism
  • Carrier Proteins / metabolism
  • Cytoskeleton / metabolism
  • Humans
  • Isoenzymes / metabolism
  • Membrane Proteins*
  • Phospholipase C gamma
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-cbl
  • Receptors, Antigen, T-Cell / physiology*
  • Signal Transduction / immunology*
  • Signal Transduction / physiology
  • Type C Phospholipases / metabolism
  • Ubiquitin-Protein Ligases*
  • ras Proteins / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Isoenzymes
  • LAT protein, human
  • Membrane Proteins
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • Receptors, Antigen, T-Cell
  • SLP-76 signal Transducing adaptor proteins
  • Proto-Oncogene Proteins c-cbl
  • Ubiquitin-Protein Ligases
  • Protein-Tyrosine Kinases
  • Type C Phospholipases
  • Phospholipase C gamma
  • ras Proteins
  • CBL protein, human
  • Calcium