CTLA-4 and T Cell Activation

Curr Opin Immunol. 1999 Jun;11(3):294-300. doi: 10.1016/s0952-7915(99)80047-8.

Abstract

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Abatacept
  • Animals
  • Antigens, CD / metabolism
  • Antigens, Differentiation / metabolism*
  • Apoptosis
  • Autoimmunity
  • B7-1 Antigen / metabolism
  • B7-2 Antigen
  • CD28 Antigens / metabolism
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • CTLA-4 Antigen
  • Cell Differentiation
  • Cell Division
  • Humans
  • Immune Tolerance
  • Immunoconjugates*
  • Ligands
  • Lymphocyte Activation
  • Membrane Glycoproteins / metabolism
  • Receptors, Immunologic / metabolism
  • Signal Transduction
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Thymus Gland / growth & development

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • B7-1 Antigen
  • B7-2 Antigen
  • CD28 Antigens
  • CD86 protein, human
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Immunoconjugates
  • Ligands
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • Abatacept