A protective role for common p21WAF1/Cip1 polymorphisms in human ovarian cancer

Int J Oncol. 1999 Jul;15(1):117-9. doi: 10.3892/ijo.15.1.117.


The objective of this study was to compare the frequency of two common p21WAF1/Cip1 gene polymorphisms in ovarian cancer patients with that in age-matched controls, from a population originating from Eastern Scotland. Both polymorphisms were found significantly less frequently in both the constitutive and tumour tissue DNA of ovarian cancer patients (3/65; 4.6%), than in that from geographically and age-matched controls (25/186; 13.4%) (p=0.0495, chi2). Furthermore, we found no p21WAF1/Cip1 gene mutations in any of the tumours, reflected by a relatively low degree of loss of heterozygosity (LOH) at the chromosomal region where the gene maps, providing further evidence that the p21WAF1/Cip1 gene is not mutated in ovarian cancer. The data suggest however, that there may potentially be a protective function for the two p21WAF1/Cip1 gene polymorphisms in the population under study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Chromosomes, Human, Pair 6 / genetics*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins / genetics*
  • Cyclins / physiology
  • DNA Mutational Analysis
  • DNA, Neoplasm / genetics*
  • Disease Progression
  • Exons / genetics
  • Female
  • Gene Frequency
  • Genes, Tumor Suppressor*
  • Humans
  • Loss of Heterozygosity
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / physiology
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Polymorphism, Genetic
  • Polymorphism, Single-Stranded Conformational
  • Scotland / epidemiology


  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • DNA, Neoplasm
  • Neoplasm Proteins