Cytoskeleton cross-talk during cell motility

FEBS Lett. 1999 Jun 4;452(1-2):96-9. doi: 10.1016/s0014-5793(99)00530-x.


Cell crawling entails the co-ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site- and dose-specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology
  • Cell Movement / physiology*
  • Cell Polarity / physiology
  • Cytoskeleton / physiology*
  • Microtubules / physiology