Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger

Cell Signal. 1999 May;11(5):309-16. doi: 10.1016/s0898-6568(99)00004-2.

Abstract

Cyclic ADP-ribose (cADPR) was discovered as a potent Ca2+-mobilising natural compound in sea urchin eggs. Recently, cADPR was reported to stimulate Ca2+ signalling in several higher eukaryotic cell systems (e.g., smooth and cardiac muscle cells, neuronal cells, adrenal chromaffin cells, macrophages, pancreatic acinar cells and T-lymphocytes). The following aspects of the role of cADPR as a Ca2+-mobilising second messenger are reviewed: coupling of metabolism of cADPR to stimulation of receptors in the plasma membrane, properties and pharmacology of Ca2+ release by cADPR and the involvement of cADPR in Ca2+ entry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Adenosine Diphosphate Ribose / analogs & derivatives*
  • Adenosine Diphosphate Ribose / metabolism
  • Animals
  • Antigens, CD*
  • Antigens, Differentiation / metabolism
  • Calcium / metabolism*
  • Calcium Signaling
  • Cyclic ADP-Ribose
  • Humans
  • Membrane Glycoproteins
  • NAD+ Nucleosidase / metabolism
  • Receptors, Cell Surface / metabolism
  • Second Messenger Systems*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Cyclic ADP-Ribose
  • Adenosine Diphosphate Ribose
  • ADP-ribosyl Cyclase
  • CD38 protein, human
  • NAD+ Nucleosidase
  • ADP-ribosyl Cyclase 1
  • Calcium