Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

Br J Cancer. 1999 Jun;80(8):1262-4. doi: 10.1038/sj.bjc.6690495.


Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Breast Neoplasms / genetics*
  • Carcinoma / genetics*
  • DNA Methylation*
  • DNA, Neoplasm / blood*
  • Female
  • Genes, p16 / genetics*
  • Humans
  • Molecular Sequence Data


  • DNA, Neoplasm