Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension

J Clin Invest. 1999 Jun;103(12):1651-7. doi: 10.1172/JCI6691.


Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Congenic
  • Blood Glucose / genetics
  • Blood Glucose / metabolism
  • CD36 Antigens / genetics*
  • Cerebrovascular Disorders / genetics
  • Cerebrovascular Disorders / physiopathology
  • Cluster Analysis
  • Genotype
  • Hemodynamics / genetics
  • Hypertension / genetics*
  • Hypertension / physiopathology
  • Insulin / blood
  • Insulin / genetics
  • Lipids / blood
  • Lipids / genetics
  • Phenotype
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred SHR
  • Risk Factors
  • Sequence Deletion


  • Blood Glucose
  • CD36 Antigens
  • Insulin
  • Lipids