The trithorax-group and polycomb-group chromatin modifiers: implications for disease

Curr Opin Genet Dev. 1999 Jun;9(3):355-61. doi: 10.1016/s0959-437x(99)80053-7.

Abstract

The chromatin structure associated transcriptional memory function by Polycomb-group and trithorax-group protein complexes integrate normal development with control of cellular proliferation. This is illustrated by recent mechanistic insights that link Polycomb repression with histone deacetylases and the identification of new target genes that provide a connection to cell cycle control and tumorigenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Chromatin / genetics*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Drosophila Proteins*
  • Humans
  • Insect Proteins / genetics
  • Insect Proteins / physiology*
  • Leukemia / genetics*
  • Polycomb Repressive Complex 1
  • Transcription Factors*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Insect Proteins
  • Pc protein, Drosophila
  • Transcription Factors
  • Trl protein, Drosophila
  • Polycomb Repressive Complex 1