Development of the mammalian enteric nervous system

Curr Opin Genet Dev. 1999 Jun;9(3):321-7. doi: 10.1016/s0959-437x(99)80048-3.


The mammalian enteric nervous system is derived from neural crest cells which invade the foregut and hindgut mesenchyme. It has been established that signalling molecules produced by the mesenchyme of the gut wall play a critical role in the development of the mammalian enteric nervous system. Recent studies have characterised further the role of such molecules and have identified novel extracellular and intracellular signals that are critical for enteric ganglia formation.

Publication types

  • Review

MeSH terms

  • Animals
  • Embryonic and Fetal Development / physiology
  • Enteric Nervous System / cytology
  • Enteric Nervous System / embryology*
  • Mammals
  • Signal Transduction
  • Stem Cells / cytology