Antibiotic peptides from higher eukaryotes: biology and applications

Mol Med Today. 1999 Jul;5(7):292-7. doi: 10.1016/s1357-4310(99)01490-2.


Gene-encoded antibiotic peptides are increasingly being recognized as effector molecules of host defense in plants and animals. Studies of antimicrobial peptides are providing new insights into the dynamic interactions between microbes and their hosts, and are generating new paradigms for the pathogenesis and treatment of diseases. Because antimicrobial peptides of higher eukaryotes differ structurally from conventional antibiotics produced by bacteria and fungi, they offer novel templates for pharmaceutical compounds that could be effective against increasingly resistant microbes.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / metabolism
  • Anti-Infective Agents* / pharmacology
  • Bacteria / drug effects
  • Eukaryotic Cells / metabolism*
  • Fungi / drug effects
  • Peptide Biosynthesis
  • Peptides* / chemistry
  • Peptides* / pharmacology
  • Viruses / drug effects


  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Peptides