Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis

Cancer Lett. 1999 Apr 26;138(1-2):53-9. doi: 10.1016/s0304-3835(98)00372-3.


Thirty-eight oral squamous cell carcinomas (SCCs) were semi-quantitatively analyzed by immunohistochemical staining, and the relation between heme oxygenase-1 (HO-1) expression and the clinical status were correlated. High immunostaining of HO-1 was detected in lymph node metastasis negative groups (P = 0.0018) and in well-differentiated SCCs (P = 0.0016). There were no significant correlations between heme oxygenase-1 expression and other factors, such as size of the tumor, staging, age and sex. These findings further support the proposition that high heme oxygenase-1 expression in oral SCCs can be useful in identifying patients at low risk of lymph node metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / enzymology*
  • Carcinoma, Squamous Cell / secondary
  • Female
  • Heme Oxygenase (Decyclizing) / genetics
  • Heme Oxygenase (Decyclizing) / metabolism*
  • Heme Oxygenase-1
  • Humans
  • Lymphatic Metastasis
  • Male
  • Membrane Proteins
  • Middle Aged
  • Mouth Neoplasms / enzymology*
  • Mouth Neoplasms / pathology
  • Prognosis


  • Membrane Proteins
  • HMOX1 protein, human
  • Heme Oxygenase (Decyclizing)
  • Heme Oxygenase-1