Cytokine/chemokine cascades in immunity to tuberculosis

Immunol Today. 1999 Jul;20(7):307-12. doi: 10.1016/s0167-5699(98)01438-8.

Abstract

The relationship between acquired specific resistance and delayed-type hypersensitivity (DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and Andrea Cooper propose that the events are separate mechanisms; protection is cytokine driven and initially controls the infection, whereas DTH is primarily chemokine driven and functions to wall off the infection and prevent further dissemination.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chemokines / physiology*
  • Cytokines / physiology*
  • Humans
  • Hypersensitivity, Delayed
  • Lung / immunology
  • Mice
  • Models, Biological
  • T-Lymphocytes / immunology
  • Tuberculosis, Pulmonary / immunology*

Substances

  • Chemokines
  • Cytokines