CD5 expression in human B-cell populations

Immunol Today. 1999 Jul;20(7):312-6. doi: 10.1016/s0167-5699(99)01476-0.


The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells. Here, Pierre Youinou, Christophe Jamin and Peter Lydyard review current knowledge of B-1 and B-2 cells, and propose that CD5 has different functions when expressed by different B-cell subpopulations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Antigens, Differentiation, B-Lymphocyte / metabolism
  • Apoptosis
  • B-Lymphocyte Subsets / cytology
  • B-Lymphocyte Subsets / immunology*
  • CD5 Antigens / metabolism*
  • Cell Division
  • Humans
  • Ligands
  • Lymphocyte Activation


  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • CD5 Antigens
  • CD72 protein, human
  • Ligands