T-cell function in newborn mice and humans

Immunol Today. 1999 Jul;20(7):330-5. doi: 10.1016/s0167-5699(99)01473-5.

Abstract

Neonates mount poor immune responses, and it has been assumed that neonatal T cells differ qualitatively from adult T cells. Here, Becky Adkins discusses this issue in the light of recent data indicating that T cells in neonates are developmentally mature in their capacity to mount protective Th1-type and cytotoxic T lymphocyte responses.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Animals, Newborn
  • B-Lymphocytes / immunology
  • Cell Differentiation
  • Cytokines / biosynthesis
  • Fetal Blood / cytology
  • Fetal Blood / immunology
  • Humans
  • In Vitro Techniques
  • Infant, Newborn / immunology*
  • Mice
  • Models, Biological
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / cytology
  • T-Lymphocytes, Cytotoxic / immunology
  • Th1 Cells / cytology
  • Th1 Cells / immunology

Substances

  • Cytokines