Fast FLAIR sequence for detecting major vascular abnormalities during the hyperacute phase of stroke: a comparison with MR angiography

Neuroradiology. 1999 May;41(5):342-6. doi: 10.1007/s002340050761.


In the hyperacute phase of stroke, occluded vessels can be seen as high signal on fast-FLAIR images or as absence of flow-related enhancement in maximum-intensity projection (MIP) MR angiography (MRA). To compare these techniques, we examined 53 patients within 6 h of a stroke, using a standardised MRI protocol including fast-FLAIR and 3D time-of-flight TOF MR to detect vessel occlusion or reduced flow corresponding to the suspected ischaemic territory. Brain infarcts were confirmed on MRI after 1-5 days in 41 cases (77%). The overall accuracy of 3D-TOF MRA was 68% and sensitivity, specificity, positive and negative predictive values were 67%, 71%, 87%, and 43% respectively. Values for the fast-FLAIR sequence were: 65%, 85%, 93% and 44%, with an overall accuracy of 70%. The fast-FLAIR sequence was thus able to show occluded vessels or reduced flow with about the same accuracy as 3D-TOF MRA and enabled better prediction of the ischaemic area.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cerebrovascular Circulation*
  • Cerebrovascular Disorders / diagnosis*
  • Female
  • Humans
  • Magnetic Resonance Angiography*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Sensitivity and Specificity