Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives

Biosci Biotechnol Biochem. 1999 May;63(5):955-7. doi: 10.1271/bbb.63.955.

Abstract

Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation system. The inhibition of TBARS formation occurred with N-acylated 9-mer peptides with a core sequence of LFcin B and, compared to LFcin B, their antioxidant effect was clearly observed at a concentration almost 100 times lower.

MeSH terms

  • Acylation
  • Amino Acid Sequence
  • Animals
  • Ascorbic Acid / pharmacology*
  • Cattle
  • Iron / pharmacology*
  • Lactoferrin / chemistry*
  • Lipid Peroxidation / drug effects*
  • Molecular Sequence Data
  • Peptide Fragments / pharmacology*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Peptide Fragments
  • Thiobarbituric Acid Reactive Substances
  • Iron
  • Lactoferrin
  • Ascorbic Acid