A Striking Organization of a Large Family of Human Neural Cadherin-Like Cell Adhesion Genes

Cell. 1999 Jun 11;97(6):779-90. doi: 10.1016/s0092-8674(00)80789-8.

Abstract

We have identified 52 novel human cadherin-like genes organized into three closely linked clusters. Comparison of the genomic DNA sequences with those of representative cDNAs reveals a striking genomic organization similar to that of immunoglobulin and T cell receptor gene clusters. The N-terminal extracellular and transmembrane domains of each cadherin protein are encoded by a distinct and unusually large exon. These exons are organized in a tandem array. By contrast, the C-terminal cytoplasmic domain of each protein is identical and is encoded by three small exons located downstream from the cluster of N-terminal exons. This unusual organization has interesting implications regarding the molecular code required to establish complex networks of neuronal connections in the brain and the mechanisms of cell-specific cadherin-like gene expression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Cadherins / classification
  • Cadherins / genetics*
  • Cell Adhesion / genetics*
  • Chromosomes, Human, Pair 5
  • DNA, Complementary
  • Evolution, Molecular
  • Gene Expression Regulation
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • Multigene Family*
  • Protein Precursors / classification
  • Protein Precursors / genetics
  • RNA, Messenger
  • Sequence Homology, Amino Acid

Substances

  • Cadherins
  • DNA, Complementary
  • Protein Precursors
  • RNA, Messenger

Associated data

  • GENBANK/AF152303
  • GENBANK/AF152304
  • GENBANK/AF152305
  • GENBANK/AF152306
  • GENBANK/AF152307
  • GENBANK/AF152308
  • GENBANK/AF152309
  • GENBANK/AF152310
  • GENBANK/AF152311
  • GENBANK/AF152312
  • GENBANK/AF152313
  • GENBANK/AF152314
  • GENBANK/AF152315
  • GENBANK/AF152316
  • GENBANK/AF152317
  • GENBANK/AF152318
  • GENBANK/AF152319
  • GENBANK/AF152320
  • GENBANK/AF152321
  • GENBANK/AF152322
  • GENBANK/AF152323
  • GENBANK/AF152324
  • GENBANK/AF152325
  • GENBANK/AF152326
  • GENBANK/AF152327
  • GENBANK/AF152328
  • GENBANK/AF152329
  • GENBANK/AF152330
  • GENBANK/AF152331
  • GENBANK/AF152332